Efficacy of pegylated Graphene oxide quantum dots as a nanoconjugate sustained release metformin delivery system in in vitro insulin resistance model.
Kunal SarkarArindam ChatterjeeBiswabandhu BankuraSarbashri BankNirvika PaulSrilagna ChatterjeeAnwesha DasKoushik DuttaSantanu ChakrabortySriparna DeAlaa A Al-MasudGausal Azam KhanDipankar ChattopadhyayMadhusudan DasPublished in: PloS one (2024)
Metformin, the primary therapy for type 2 diabetes mellitus (T2DM), showed limitations such as varying absorption, rapid system clearance, required large amount, resistance, longstanding side effects. Use of Nano formulations for pharmaceuticals is emerging as a viable technique to reduce negative consequences of drug, while simultaneously attaining precise release and targeted distribution. This study developed a Polyethylene Glycol conjugated Graphene Oxide Quantum dots (GOQD-PEG) nanocomposite for the sustained release of metformin. Herein, we evaluated the effectiveness of metformin-loaded nanoconjugate in in vitro insulin resistance model. Results demonstrated drug loaded nanoconjugate successfully restored glucose uptake and reversed insulin resistance in in vitro conditions at reduced dosage compared to free metformin.
Keyphrases
- quantum dots
- insulin resistance
- drug delivery
- cancer therapy
- type diabetes
- metabolic syndrome
- randomized controlled trial
- sensitive detection
- glycemic control
- systematic review
- polycystic ovary syndrome
- skeletal muscle
- photodynamic therapy
- cardiovascular disease
- emergency department
- blood pressure
- adverse drug
- blood glucose
- electronic health record
- carbon nanotubes