Assessing the Significance of the Circadian Time of Administration on the Effectiveness and Tolerability of OnabotulinumtoxinA for Chronic Migraine Prophylaxis.

Emmanouil V Dermitzakis Michail Vikelis George S Vlachos Haralabos P Kalofonos

Published in: Toxins (2022)

We were not able to identify significant differences between patients treated in the AM vs. PM, so as to demonstrate that the circadian time of administration should be considered before initiating BoNTA in CM patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
randomized controlled trial
chronic kidney disease
prognostic factors
particulate matter
open label
patient reported outcomes
risk assessment