A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma.

Hidenori AndoNoriko Saito-TarashimaAmr S Abu LilaNozomi KinjoTaro ShimizuYu IshimaNoriaki MinakawaTatsuhiro Ishida

Published in: Molecules (Basel, Switzerland) (2020)

Local delivery of iRed could augment the in vivo gene silencing effect without eliciting pronounced innate immune stimulation. Our results might hold promise for widespread utilization of iRed as an RNAi-based therapeutic for intracelial malignant cancers.

Keyphrases

innate immune
poor prognosis
big data
ultrasound guided
binding protein
young adults
artificial intelligence
childhood cancer