Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer.
Flavia Rotea MangoneMaira Av ValoyesRenan G do NascimentoMércia Pf ConceiçãoDaniel R BastosAna C PavanelliIberê C SoaresEvandro S de MelloSuely NonogakiCynthia Ab de T OsórioMaria Aparecida NagaiPublished in: Biomarkers in medicine (2020)
Aim: The PHLDA (pleckstrin homology like domain, family A) gene family encodes proteins capable of inhibiting AKT (serine/threonine kinase) signaling through phosphoinositol binding competition. Results & methodology: Using in silico analysis, we found that Luminal A and B patients' short relapse-free survival was associated with low PHLDA1 or PHLDA3 and high PHLDA2 expression. In a cohort of 393 patients with luminal breast cancer evaluated by immunohistochemistry on tissue microarrays, we found a direct association of PHLDA3 expression with hormonal therapy response (p = 0.013). Conclusion: Our findings provide new information on the role played by the PHLDA family members as prognostic markers in breast cancer, and more importantly, we provide evidence that they might also predict a response to endocrine therapy.
Keyphrases
- free survival
- poor prognosis
- signaling pathway
- end stage renal disease
- protein kinase
- ejection fraction
- binding protein
- newly diagnosed
- chronic kidney disease
- prognostic factors
- cell proliferation
- long non coding rna
- type diabetes
- stem cells
- molecular docking
- patient reported outcomes
- dna binding
- molecular dynamics simulations
- insulin resistance
- breast cancer risk