Effectiveness of Dual Medication Therapy (Oral Acetaminophen and Oral Ibuprofen) for the Management of Patent Ductus Arteriosus in Extremely Premature Infants: A Feasibility Trial.

Sanket D ShahKartikeya MakkerPadma NandulaCarmen SmothermanAndrea KropfMark L Hudak

Published in: American journal of perinatology (2021)

· No consensus on optimal medication for PDA treatment is available.. · Dual oral medication therapy (ibuprofen and acetaminophen) could be an effective alternative treatment for PDA.. · Dual oral medication therapy (ibuprofen and acetaminophen) may have a better safety profile than currently approved medications such as intravenous indomethacin and intravenous ibuprofen..

Keyphrases

healthcare
adverse drug
randomized controlled trial
systematic review
clinical trial
liver injury
high dose
study protocol
emergency department
replacement therapy
low dose
clinical practice
phase ii
open label