Wheeze trajectories are modifiable through early-life intervention and predict asthma in adolescence.
Arthur H OworaAllan B BeckerMoira Chan-YeungEdmond S ChanRishma ChooniedassClare RamseyWade T A WatsonMeghan B AzadPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)
Using data-driven methodology, children can be classified into clinically meaningful wheeze trajectory groups that appear to be programmed by modifiable and non-modifiable factors, and are useful for predicting asthma risk. Early-life interventions can alter some wheeze trajectories (ie, Early-Persistent) in infancy and reduce wheezing prevalence in mid-childhood.