Omega-3 polyunsaturated fatty acids exert anti-oxidant effects through the nuclear factor (erythroid-derived 2)-related factor 2 pathway in immortalized mouse Schwann cells.
Yasuaki TatsumiAyako KatoKazunori SangoTatsuhito HimenoMasaki KondoYoshiro KatoHideki KamiyaJiro NakamuraKoichi KatoPublished in: Journal of diabetes investigation (2018)
These findings show that DHA and EPA can induce Ho-1 and catalase through Nrf2, thus protecting Schwann cells against oxidative stress. ω-3 PUFAs appear to exert their neuroprotective effect by increasing defense mechanisms against oxidative stress in diabetic neuropathies.
Keyphrases
- induced apoptosis
- oxidative stress
- nuclear factor
- cell cycle arrest
- endoplasmic reticulum stress
- toll like receptor
- dna damage
- signaling pathway
- type diabetes
- ischemia reperfusion injury
- diabetic rats
- cell death
- peripheral nerve
- pi k akt
- inflammatory response
- wound healing
- fatty acid
- cerebral ischemia
- cell proliferation