ZFP36 Inhibits Tumor Progression of Human Prostate Cancer by Targeting CDK6 and Oxidative Stress.
Dongbo YuanYinyi FangWeiming ChenKehua JiangGuohua ZhuWei WangWei ZhangGanhua YouZhenyu JiaJianguo ZhuPublished in: Oxidative medicine and cellular longevity (2022)
In PCa, ZFP36 might be a tumor suppressor that regulated growth, invasion, and migration of PCa cells. The lately discovered ZFP36-CDK6 axis demonstrated the molecular mechanism of PCa progression to a certain extent which might act as a new possible therapeutic target of PCa therapy.
Keyphrases
- prostate cancer
- induced apoptosis
- oxidative stress
- cell cycle
- endothelial cells
- radical prostatectomy
- cell cycle arrest
- poor prognosis
- dna damage
- endoplasmic reticulum stress
- induced pluripotent stem cells
- cell death
- cell migration
- mesenchymal stem cells
- diabetic rats
- bone marrow
- long non coding rna
- pi k akt
- replacement therapy