DOCK2 (Dedicator of Cytokinesis 2) Deficiency Attenuates Abdominal Aortic Aneurysm Formation.

Xia GuoDunpeng CaiKun DongChenxiao LiZaiyan XuShi-You Chen

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our results indicate that DOCK2 is a novel regulator for AAA formation. DOCK2 regulates AAA development by promoting MCP-1 and MMP2 expression to incite vascular inflammation and elastin degradation.

Keyphrases

abdominal aortic aneurysm
poor prognosis
oxidative stress
transcription factor
long non coding rna