A Randomized, Controlled Neuroimaging Trial of Cognitive-Behavioral Therapy for Fibromyalgia Pain.

Jeungchan LeeAsimina LazaridouMyrella PaschaliMarco L LoggiaMichael P BerryDan-Mikael EllingsenKylie IsenburgAlessandra AnzolinArvina GrahlAjay D WasanVitaly NapadowRobert R Edwards

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Our results suggest clinically important and CBT-specific associations between somatosensory/motor- and salience-processing brain regions and the default mode network in chronic pain. These patterns of connectivity may contribute to individual differences (and treatment-related changes) in somatic self-awareness. CBT appears to provide clinical benefits at least partially by reducing pain-related catastrophizing and producing adaptive alterations in default mode network functional connectivity.

Keyphrases

functional connectivity
chronic pain
resting state
pain management
randomized controlled trial
gene expression
study protocol
neuropathic pain
open label
subarachnoid hemorrhage