Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis.
Satoru YonekuraSafae TerrisseCarolina Alves Costa SilvaAntoine LafargeValerio IebbaGladys FerrereAnne-Gaëlle GoubetJean-Eudes FahrnerImran LahmarKousuke UedaGibrail MansouriEugénie PizzatoPierre LyMarine MazzengaCassandra ThelemaqueMarine FidelleFanny JaulinJérôme CartryMarc DelogerMarine AglaveNathalie M DroinPaule OpolonAngélique PugetFanny MannMichel NeunlistAnne BessardLaetitia AymericTamara Matysiak-BudnikJacques BosqPaul HofmanConnie P M DuongSophie UgoliniValentin QuiniouSylvie BerrardBernhard RyffelOliver KeppGuido KroemerBertrand RoutyLeonardo LordelloMohamed Amine BaniNicola SegataFjodor Yousef YengejHans CleversJean Yves ScoazecEdoardo PasolliLisa DerosaLaurence ZitvogelPublished in: Cancer discovery (2022)
Whether gut dysbiosis promotes tumorigenesis and how it controls tumor progression remain open questions. We show that 50% of transplantable extraintestinal malignancies triggered a β-adrenergic receptor-dependent ileal mucosa atrophy, associated with increased gut permeability, sustained Clostridium spp.-related dysbiosis, and cancer growth. Vancomycin or propranolol prevented cancer-associated stress ileopathy. This article is highlighted in the In This Issue feature, p. 873.