Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration.
Clemens MuehlanMargaux BoehlerSander BrooksRob G J A ZuikerJoop van GervenJasper DingemansePublished in: Journal of psychopharmacology (Oxford, England) (2019)
ACT-541468 in elderly subjects was well tolerated and pharmacokinetics and pharmacodynamics are compatible with a drug for the treatment of insomnia. Clinicaltrials.gov: NCT02571855.