DPP4 Activity, Hyperinsulinemia, and Atherosclerosis.
Kaitlin M LoveZhenqi LiuPublished in: The Journal of clinical endocrinology and metabolism (2021)
DPP4 may represent a key link between central obesity, insulin resistance, and atherosclerosis. The gaps in knowledge in DPP4 function and discrepancy in cardiovascular outcomes observed in preclinical and large-scale randomized controlled studies with DPP4 inhibitors warrant additional research.
Keyphrases
- insulin resistance
- metabolic syndrome
- cardiovascular disease
- type diabetes
- healthcare
- adipose tissue
- high fat diet
- skeletal muscle
- weight loss
- double blind
- open label
- polycystic ovary syndrome
- clinical trial
- randomized controlled trial
- weight gain
- phase ii
- mesenchymal stem cells
- body mass index
- physical activity
- case control
- glycemic control