Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.

Xin-Yu ChenBin LiYe WangJuan JinYu YangLei-Huan HuangMeng-Di YangJian ZhangBi-Yun WangZhi-Ming ShaoTing NiSheng-Lin HuangXi-Chun Hu Zhong-Hua Tao

Published in: Cancer communications (London, England) (2023)

In AIR epigenetics, low ARID1A expression in TNBC contributed to AIR via the ARID1A/NPM1/PD-L1 axis, leading to poor outcome but sensitivity to ICI treatment.

Keyphrases

poor prognosis
acute myeloid leukemia
induced apoptosis
binding protein
oxidative stress
signaling pathway
endoplasmic reticulum stress