Platform trial for off-label oncology drugs using comprehensive genomic profiling under the universal public healthcare system: the BELIEVE trial.

Sae IshimaruTatsunori ShimoiKuniko SunamiMiho NakajimaYayoi AndoNatsuko OkitaKenichi NakamuraTaro ShibataYasuhiro FujiwaraNoboru Yamamoto

Published in: International journal of clinical oncology (2023)

The BELIEVE trial provides hope for patients with actionable genetic abnormalities by facilitating access to targeted therapies through off-label drug administration. It establishes a regulatory framework and promotes collaboration between industry and academia by expanding organ-specific and cross-organ biomarker-based treatments.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
drug administration
healthcare
open label
copy number
randomized controlled trial
palliative care
emergency department
gene expression
high throughput
genome wide
dna methylation