Early-onset metastatic and clinically advanced prostate cancer is a distinct clinical and molecular entity characterized by increased TMPRSS2-ERG fusions.

Zachary R Chalmers Michael C BurnsEricka M EbotGarrett M FramptonJeffery S Ross Maha H A Hussain Sarki A Abdulkadir

Published in: Prostate cancer and prostatic diseases (2021)

Clinically advanced and metastatic early-onset prostate cancer is a distinct clinical subgroup with characteristic genomic alterations including increased frequency of TMPRSS2-ERG fusions and fewer AR, SPOP, and ASXL1 alterations.

Keyphrases

early onset
prostate cancer
late onset
radical prostatectomy
squamous cell carcinoma
small cell lung cancer
clinical trial
randomized controlled trial
gene expression
copy number
study protocol
single molecule