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Role of Olive Bioactive Compounds in Respiratory Diseases.

Ubashini VijakumaranNeng-Yao GohRabiatul Adawiyah RazaliNur Atiqah Haizum AbdullahMuhammad Da'in YazidNadiah S Sulaiman
Published in: Antioxidants (Basel, Switzerland) (2023)
Respiratory diseases recently became the leading cause of death worldwide, due to the emergence of COVID-19. The pathogenesis of respiratory diseases is centred around inflammation and oxidative stress. Plant-based alongside synthetic drugs were considered as therapeutics due to their proven nutraceutical value. One such example is the olive, which is a traditional symbol of the MedDiet. Olive bioactive compounds are enriched with antioxidant, anti-inflammatory, anticancer and antiviral properties. However, there are few studies relating to the beneficial effect of olive bioactive compounds on respiratory diseases. A vague understanding of its molecular action, dosage and bioavailability limits its usefulness for clinical trials about respiratory infections. Hence, our review aims to explore olive bioactive compound's antioxidant, anti-inflammatory and antiviral properties in respiratory disease defence and treatment. Molecular insight into olive compounds' potential for respiratory system protection against inflammation and ensuing infection is also presented. Olive bioactive compounds mainly protect the respiratory system by subsiding proinflammatory cytokines and oxidative stress.
Keyphrases
  • oxidative stress
  • anti inflammatory
  • clinical trial
  • respiratory tract
  • dna damage
  • randomized controlled trial
  • induced apoptosis
  • small molecule
  • diabetic rats
  • signaling pathway
  • drug induced
  • study protocol
  • double blind