A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance.

Sara C SebagQingwen QianChawin UparaQiong DingHuojun CaoLiu HongLing Yang

Published in: bioRxiv : the preprint server for biology (2023)

here we investigated its role in modulating high-fat diet (HFD)-induced metabolic dysfunction. In a murine model of obesity, we found 6-HHA-mediated improvement of diet-mediated adiposity, insulin resistance and inflammation were in part due to actions on white adipose tissue (WAT).6-HHA suppressed proinflammatory cytokine production and lipolysis through Gi-mediated signaling in differentiated white adipocytes.

Keyphrases

insulin resistance
high fat diet
adipose tissue
high fat diet induced
polycystic ovary syndrome
metabolic syndrome
skeletal muscle
fatty acid
type diabetes
oxidative stress
physical activity
weight loss
diabetic rats
signaling pathway
glycemic control
body mass index
high glucose
weight gain
drug induced