Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival.
Tatiana V KudryashovaSwati DabralSreenath NayakantiArnab RayDmitry A GoncharovTheodore AvolioYuanjun ShenAnalise RodeAndressa PenaLifeng JiangDerek LinJeffrey BaustTimothy N BachmanJohannes GraumannClemens RuppertAndreas GuentherMario SchmoranzerYann GrobsSarah Eve LemayEve TremblaySandra Breuils-BonnetOlivier BoucheratAna L MoraHorace DeLisserJing ZhaoYutong ZhaoSebastien BonnetHorst-Walter BirkSoni S PullamsettiElena A GoncharovaPublished in: Circulation research (2022)
Together, this study describes a novel proproliferative/prosurvival role of MST1/2 in PAH pulmonary vasculature, provides a novel mechanistic link from MST1/2 via BUB3 and forkhead homeobox type O to the abnormal proliferation and survival of pulmonary arterial vascular smooth muscle cells and pulmonary arterial adventitial fibroblasts, remodeling and pulmonary hypertension, and suggests new target pathways for therapeutic intervention.