Characterization of EpCAM in thyroid cancer biology by three-dimensional spheroids in vitro model.

Viola Ghiandai Elisa Stellaria Grassi Giacomo Gazzano Laura Fugazzola Luca Persani

Published in: Cancer cell international (2024)

Our data provide novel information on the role of EpCAM expression and cleavage in the biology of thyroid TICs, and our 3D model reflects the variability of EpCAM cleavage observed in tissue samples. EpCAM evaluation could play a role in clinical decisions regarding patient therapy since its expression and cleavage may have a fundamental role in the switch to a drug-resistant phenotype of UTC cells.

Keyphrases

drug resistant
cell adhesion
circulating tumor cells
poor prognosis
multidrug resistant
dna binding
acinetobacter baumannii
induced apoptosis
binding protein
electronic health record
transcription factor
big data
signaling pathway
health information
pi k akt
smoking cessation