Lipid-Based Self-Microemulsion of Niclosamide Achieved Enhanced Oral Delivery and Anti-Tumor Efficacy in Orthotopic Patient-Derived Xenograft of Hepatocellular Carcinoma in Mice.

Yi LiuDavid Quintanar GuerreroDavid Lechuga-BallesterosMingdian TanFaiz AhmadBilal AleiwiEdmund Lee EllsworthBin ChenMei-Sze ChuaSamuel So

Published in: International journal of nanomedicine (2024)

We successfully developed an orally bioavailable formulation of niclosamide, which significantly enhanced oral bioavailability and anti-tumor efficacy in an HCC PDX mouse model. Our data support its clinical translation for the treatment of solid tumors.

Keyphrases

mouse model
drug delivery
electronic health record
high fat diet induced
type diabetes
fatty acid
machine learning
adipose tissue
metabolic syndrome
skeletal muscle