Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces .
Kantinan LeetanasaksakulWilaiwan KoomsiriTakuya SugaHirotaka MatsuoRei HokariPakorn Wattana-AmornYo Ko TakahashiKazuro ShiomiTakuji NakashimaYuki InahashiArinthip ThamchaipenetPublished in: Journal of natural products (2022)
Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum , antibiofilm formation of Escherichia coli , and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.
Keyphrases
- escherichia coli
- plasmodium falciparum
- endothelial cells
- genome wide
- papillary thyroid
- gram negative
- copy number
- gene expression
- induced pluripotent stem cells
- big data
- pseudomonas aeruginosa
- multidrug resistant
- mass spectrometry
- lymph node metastasis
- machine learning
- deep learning
- pluripotent stem cells
- artificial intelligence
- gas chromatography
- childhood cancer
- data analysis
- high resolution