Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network.
Alessio SignoriJohannes LorscheiderSandra VukusicMaria TrojanoPietro IaffaldanoJan A HillertRobert HydeFabio PellegriniMelinda MagyariNils Koch-HenriksenPer Soelberg SørensenTim SpelmanAnneke Van Der WaltDana HorakovaEva HavrdovaMarc GirardSara EichauFrancois Grand'MaisonOliver GerlachMurat TerziSerkan OzakbasOlga SkibinaVincent Van PeschMaria Jose SaJulie PrevostRaed AlroughaniPamela A McCombeRiadh GoudierSaloua MrabetTamara Castillo TriviñoChao ZhuKoen de GansJosé Luis Sánchez-MenoyoBassem YamoutSamia Joseph KhouryMaria Pia SormaniTomas KalincikHelmut Butzkuevennull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Contrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.