Pathogenesis and Management of Acute Necrotizing Encephalopathy.
Ningxiang QinJing WangXi PengLiang WangPublished in: Expert review of neurotherapeutics (2023)
ANE is a type of necrotizing lesion of the brain parenchyma. There are two major types of reported cases. One is isolated and sporadic ANE, which is primarily caused by viral infections, particularly influenza and HHV-6 virus. The other type is familial recurrent ANE, which is caused by RANBP2 gene mutations. ANE patients have rapid progression and a very poor prognosis, with acute brain dysfunction occurring within days of viral infection and requiring admission to the intensive care unit. Clinicians still need to investigate and find solutions for the problems of early detection and treatment of ANE.
Keyphrases
- poor prognosis
- liver failure
- end stage renal disease
- long non coding rna
- respiratory failure
- early onset
- white matter
- resting state
- mental health
- ejection fraction
- chronic kidney disease
- newly diagnosed
- emergency department
- sars cov
- oxidative stress
- late onset
- cerebral ischemia
- palliative care
- hepatitis b virus
- brain injury
- blood brain barrier
- subarachnoid hemorrhage
- acute respiratory distress syndrome
- multiple sclerosis
- mechanical ventilation