Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia.
Shigekuni OkumuraSayuki OkaTakako SasakiMarion A CooleyYuko HidakaHana InoueHitoshi NishijimaShin-Ichiro OhnoShota TanifujiMari KanekoTakaya AbeMasahiko KurodaTadashi YokosukaRichard M BreyerHiroshi HommaYuko KatoUtako YokoyamaPublished in: Cardiovascular research (2024)
EP4 was upregulated in VSMCs of proliferative IH, and EP4 signaling promoted IH, at least in part through fibulin-1. An EP4 antagonist might be considered as a therapeutic strategy for IH.