Oxygen-enhanced MRI detects incidence, onset and heterogeneity of radiation-induced hypoxia modification in HPV-associated oropharyngeal cancer.
Michael J DubecJames M PriceMichael BerksJohn GaffneyRoss A LittleNuria PortaNivetha SridharanAnubhav DattaDamien J McHughChristina J HagueSusan CheungPrakash ManoharanMarcel B van HerkAnanya ChoudhuryJulian C MatthewsGeoffrey J M ParkerDavid L BuckleyKevin J HarringtonAndrew J McPartlinJames P B O'ConnorPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Radiation-induced hypoxia modification can occur as early as W2, but onset varies between patients and was not necessarily associated with overall size change. Half of all patients had discordant changes in primary and nodal tumors. These findings have implications for patient selection and timing of dose de-escalation strategies in HPV-associated oropharyngeal carcinoma.
Keyphrases
- radiation induced
- end stage renal disease
- ejection fraction
- radiation therapy
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- randomized controlled trial
- endothelial cells
- clinical trial
- squamous cell carcinoma
- patient reported outcomes
- magnetic resonance
- papillary thyroid
- neoadjuvant chemotherapy
- study protocol