Involvement of STAT3 in the synergistic induction of 11β-HSD1 by SAA1 and cortisol in human amnion fibroblasts.

Yi LuQiong ZhouJiang-Wen LuWang-Sheng WangKang Sun

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

This study has demonstrated that SAA1 and cortisol can reinforce each other in the induction of 11β-HSD1 expression through sequential phosphorylation of STAT3. The synergistic enhancement of 11β-HSD1 expression by SAA1 and cortisol may lead to excessive cortisol accumulation in the fetal membranes at parturition.

Keyphrases

poor prognosis
endothelial cells
cell proliferation
cancer therapy
binding protein
long non coding rna
weight gain
extracellular matrix
body mass index
drug delivery