CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.

Sumanta Kumar Pal Ben Tran John B A G Haanen Michael E Hurwitz Adrian Sacher Nizar M Tannir L Elizabeth Elizabeth Budde Simon James Harrison Sebastian Klobuch Sagar S Patel Luis Meza Mary-Lee Dequeant Anna Ma Qiuling Ally He Leah M Williams Alissa Keegan Ellen B Gurary Henia Dar Sushant Karnik Changan Guo Heidi Heath Rachel R Yuen Phuong K Morrow Archana M Agarwal Samer A Srour

Published in: Cancer discovery (2024)

Although the role of CAR T cells is well established in hematologic malignancies, the clinical experience in solid tumors has been disappointing. This clinical trial demonstrates the first complete response in a patient with RCC, reinforcing the potential benefit of CAR T cells in the treatment of solid tumors.

Keyphrases

cell therapy
clinical trial
stem cell transplantation
stem cells
mesenchymal stem cells
bone marrow
case report
renal cell carcinoma
study protocol
randomized controlled trial
combination therapy
high dose
human health
drug delivery
hematopoietic stem cell