Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma.

Allen S HoMichael LuuLaurel BarriosBonnie L BalzerShikha BoseXuemo FanEvan WalgamaJon Mallen-St ClairUsman AlamIram ShafqatDe-Chen LinYufei ChenJennifer E Van EykEllie G MaghamiGlenn D BraunsteinWendy L SacksZachary S Zumsteg

Published in: Annals of surgical oncology (2020)

Worsening histologic grade in PTC is independently associated with parallel escalation in mortality risk, on a scale approximating or surpassing established thyroid cancer risk factors. On preliminary analysis, EBRT was associated with improved survival in the most aggressive or least differentiated subvariants. Further investigation is warranted to examine the efficacy of EBRT for select poorly differentiated thyroid carcinomas.

Keyphrases

risk factors
lymph node
high grade
open label
randomized controlled trial
squamous cell carcinoma