Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.

Forrest L Baker Kyle A Smith Preteesh L Mylabathula Tiffany M Zúñiga Douglass M Diak Helena Angelica Pereira Batatinha Grace M Niemiro Michael David Seckeler Charles R Pedlar Daniel P O'Connor Jamie N Colombo Emmanuel Katsanis Richard J Simpson

Published in: Cancer research communications (2024)

Exercise mobilizes effector γδ T-cells to blood via β2-adrenergic signaling which allows for generation of a potent expanded γδ T-cell product that is highly cytotoxic against hematologic malignancies.

Keyphrases

high intensity
poor prognosis
regulatory t cells
dendritic cells
physical activity
cell proliferation
signaling pathway
resistance training
anti inflammatory
nk cells
immune response
binding protein
body composition