Oxidized polyunsaturated fatty acid promotes colitis and colitis-associated tumorigenesis in mice.

Weicang WangYuxin WangKatherine Z SanidadYige WangJianan ZhangWenqi YangQuancai SunIpek BayramRenhua SongHaixia YangDavid JohnsonHeather L ShermanDaeyoung KimLisa M MinterJustin J-L WongMelody Y ZengEric A DeckerGuodong Zhang

Published in: Journal of Crohn's & colitis (2024)

These results support that oxidized PUFA promotes the development of colitis and associated tumorigenesis in mouse models via TLR4- and gut microbiota-dependent mechanisms. Our findings highlight the potential need to update regulation policies and industrial standards for oxidized PUFA levels in food.

Keyphrases

fatty acid
low density lipoprotein
ulcerative colitis
mouse model
public health
inflammatory response
human health
immune response
wastewater treatment
high fat diet induced
metabolic syndrome
type diabetes
risk assessment
nuclear factor