DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants.

Justin Chun Cristian V RiellaHyunjae ChungShrijal S ShahMinxian WangJose M MagranerGuilherme T RibasHennrique T RibasJia-Yue ZhangSeth L AlperDavid J Friedman Martin R Pollak

Published in: Journal of the American Society of Nephrology : JASN (2022)

Lipogenesis and lipid droplet formation are important modulators of APOL1-associated cytotoxicity. Inhibition of DGAT2 may offer a potential therapeutic strategy to attenuate cytotoxic effects of APOL1 risk variants.

Keyphrases

copy number
high throughput
single cell
small molecule
fatty acid
type diabetes
gene expression
dna methylation
skeletal muscle
insulin resistance