Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine.
Han WangKathy Yuen Yee ChanChi Keung ChengMargaret H L NgPo Yi LeeFrankie Wai Tsoi ChengGrace Kee See LamTin Wai ChowShau-Yin HaAlan Kwok Shing ChiangWing-Hang LeungAnskar Yu-Hung LeungChi Chiu WangTao ZhangXiao-Bing ZhangChi Chiu SoYuet Ping YuenQiwei SunChi ZhangYaqun XuJohn Tak Kit CheungWing Hei NgPatrick Ming-Kuen TangWei KangKa-Fai ToWayne Yuk Wai LeeRaymond Siu Ming WongEllen Ngar Yun PoonQi ZhaoJunbin HuangChun ChenPatrick Man Pan YuenChi-Kong LiAlex Wing Kwan LeungKam-Tong LeungPublished in: Blood cancer discovery (2022)
We conducted integrated drug and genomic profiling of patient biopsies to build the functional genomic landscape of pediatric AML. Age-specific differences in drug response and new gene-drug interactions were identified. The feasibility of functional precision medicine-guided management of children with high-risk AML was successfully demonstrated in two evaluable clinical cases. This article is highlighted in the In This Issue feature, p. 476.