Antiviral treatment for treatment-naïve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials.

William W L WongPetros PechivanoglouJosephine WongJoanna M BieleckiAlex HainesAysegul ErmanYasmin SaeedArcturus PhoonMina TadrousMona YounisNoha Z RayadValeria RacHarry L A JanssenMurray D Krahn

Published in: Systematic reviews (2019)

Our results are consonant with current clinical guidelines and other evidence reviews. For both HBeAg-positive and HBeAg-negative populations, TDF and TAF are the most effective agents for virologic suppression, and TAF is effective across all outcomes.

Keyphrases

hepatitis b virus
randomized controlled trial
systematic review
metabolic syndrome
combination therapy
meta analyses