Occurrence of Phenylpyrazole and Diamide Insecticides in Lactating Women and Their Health Risks for Infants.

To investigate the exposure of infants to phenylpyrazole and diamide insecticides during lactation, we collected 3467 breast milk samples of lactating women from 100 cities of 24 provinces in China and prepared 100 pooled samples together city-by-city. Among phenylpyrazole insecticides, fipronil and its metabolites (63-100%) were widely detected in breast milk, with total detection concentrations ranging from 178 to 2947 ng/L (median: 921 ng/L). Among diamide insecticides, chlorantraniliprole and flubendiamide were detected in breast milk, but their detection frequencies (20-85%) and concentration levels (nondetected to 89.9 ng/L) were far lower than those of total fipronils. The average estimated daily intake of infants exposed to total fipronils through breast milk is 209 ng/kg-bw/day by upper-bound scenario evaluation, which is higher than the acceptable daily intake (200 ng/kg-bw/day). This study indicates that infants have far higher exposure levels to fipronil than adults, while exposure levels to other types of phenylpyrazoles and diamide insecticides are low.