Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial.
Gareth L AcklandAkshaykumar PatelTom E F AbbottSalma BegumPriyanthi DiasDavid R CraneSameer SomanathAlexander MiddleditchStuart ClelandAna Gutierrez Del ArroyoDavid BrealeyRupert M Pearsenull nullPublished in: European heart journal (2023)
Discontinuing RAS inhibitors before non-cardiac surgery did not reduce myocardial injury, and could increase the risk of clinically significant acute hypertension. These findings require confirmation in future studies.