RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer.

Daniel Nava RodriguesNicola CasiraghiAlessandro RomanelMateus CrespoSusana MirandaPasquale RescignoInes FigueiredoRuth RiisnaesSuzanne CarreiraSemini SumanasuriyaPaola GasperiniAdam SharpJoaquin MateoAlan MakayChristopher McNairMatthew SchiewerKaren KnudsenGunther Boysen Francesca DemichelisJohann S de Bono

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

mCRPCs have a high prevalence of RB1 genomic aberrations, with structural variants, including rearrangements, being common. Intrapatient genomic and expression heterogeneity favors RB1 aberrations as late, subclonal events that increase in prevalence due to treatment-selective pressures.

Keyphrases

copy number
single cell
genome wide
poor prognosis
small cell lung cancer
squamous cell carcinoma
dna methylation
risk factors
combination therapy