Maintenance of the human memory T cell repertoire by subset and tissue site.
Michelle MironWenzhao MengAaron M RosenfeldShirit DvorkinMaya Meimei Li PoonNora LamBrahma V KumarYoram LouzounEline T Luning PrakDonna L FarberPublished in: Genome medicine (2021)
Our results show that the human memory T cell repertoire comprises clones which persist across sites and subsets, along with clones that are more restricted to certain subsets and/or tissue sites. We also provide evidence that the tissue plays a key role in maintaining memory T cells over age, bolstering the rationale for site-specific targeting of memory reservoirs in vaccines and immunotherapies.