Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor: A phase I study in healthy young and elderly Chinese subjects.

The present study evaluated the safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor under development for the treatment of Alzheimer's disease (AD) in otherwise healthy young and elderly Chinese subjects. The study of young subjects included the multiple ascending-dose (MAD) arm (2 and 6 mg, N=24) and the food effect arm (4 mg, N=12) and was followed by the study of elderly subjects who were given (2 and 4 mg, N=11). The noncompartmental analysis method was employed to determine the pharmacokinetic parameters. The pharmacokinetics of fed versus fasted dose administration in the same subjects was assessed by 90% confidence interval (CI). In the MAD arm, the accumulation ratios of DC20 in vivo were 2.29 and 2.15, respectively. In the food effect arm, compared with fasting administration, an area under the concentration-time curve from zero to t (AUC 0-t ) after a standard and high-fat diet orally administered slightly increased by about 19% and 29%, and the T max was delayed by around 1 h. For elderly study subjects, T max was 1.5 and 1.25 h, and t 1/2 was 77.1 and 74.2 h, respectively. There were no serious adverse events, while gastrointestinal reactions were the most common adverse events associated with the study drug. We predicted the safety risks of DC20 in the clinical treatment of AD, which were well tolerated by the healthy young and elderly subjects. The elimination of DC20 from the body was slower in elderly subjects than in young subjects.