Capillarisin blocks prostate-specific antigen expression on activation of androgen receptor in prostate carcinoma cells.

Ke-Hung TsuiYing-Ling ChangTsui-Hsia FengChen-Pang HouYu-Hsiang LinPei-Shan YangBing-Wei LeeHorng-Heng Juang

Published in: The Prostate (2017)

Our results indicated that Cap inhibited growth of LNCaP cells. Cap effectively suppressed androgen activation on AR-mediated transactivation, which is AR-dependent through AR degradation and dissociation of AR-Hsp90 in prostate carcinoma cells.

Keyphrases

prostate cancer
induced apoptosis
poor prognosis
benign prostatic hyperplasia
heat shock protein
cell cycle arrest
heat shock
oxidative stress
cell death
cell proliferation
long non coding rna
signaling pathway