Modulation of mRNA Expression of IL-6 and mTORC1 and Efficacy and Feasibility of an Integrated Approach Encompassing Cognitive Behavioral Therapy Along with Pregabalin for Management of Neuropathic Pain in Postherpetic Neuralgia: A Pilot Study.
Ashok Kumar SaxenaNeha BhardwajGeetanjali Tolia ChilkotiAnish MalikGaurav Kumar ThakurMegha BajajAnwesha BanerjeeBasu Dev BanerjeeArchana SingalPublished in: Pain medicine (Malden, Mass.) (2021)
A significant downregulation of mRNA expression of IL-6 was observed; however, no significant correlation was observed between NRS pain score and ΔCt values of mRNA expression of both mTORC1 gene and IL-6 gene at baseline and at the end of 12th week. In addition, we note a significant decrease in pain intensity, depressive symptoms, and pain-related catastrophizing while improving QOL was observed with the use of CBT as a clinical adjunct along with pregabalin in PHN patients.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- chronic pain
- depressive symptoms
- ejection fraction
- copy number
- pain management
- computed tomography
- newly diagnosed
- prognostic factors
- clinical trial
- genome wide identification
- obsessive compulsive disorder
- magnetic resonance imaging
- image quality
- randomized controlled trial
- physical activity
- dual energy
- deep brain stimulation