Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice.
Linde F BouwmanBianca den HamerElwin P VerveerLente J S LerinkYvonne D KromSilvère M van der MaarelJessica C de GreefPublished in: Skeletal muscle (2020)
Our data demonstrates that loss of Dnmt3b results in derepression of DUX4 in lymphoid tissues and mESCs but not in myogenic cells of D4Z4-2.5/Dnmt3bMommeD14 mice. In addition, the Smchd1MommeD1 variant seems to have a more potent role in DUX4 derepression. Our studies suggest that the immune system is particularly but differentially sensitive to D4Z4 chromatin modifiers which may provide a molecular basis for the yet underexplored immune involvement in FSHD.
Keyphrases
- dna methylation
- gene expression
- high fat diet induced
- induced apoptosis
- genome wide
- poor prognosis
- skeletal muscle
- cell cycle arrest
- transcription factor
- dna damage
- wild type
- signaling pathway
- insulin resistance
- big data
- type diabetes
- cell proliferation
- adipose tissue
- anti inflammatory
- case control
- machine learning
- pi k akt