ISG15 protects human Tregs from interferon alpha-induced contraction in a cell-intrinsic fashion.

Ilenia PacellaFrancesca Romana SpinelliMartina SeveraEleonora TimperiGloria TucciMarta ZagaglioniFulvia CeccarelliFabiana RizzoEliana M CocciaRoosheel S PatelMarta Martin-FernandezDusan BogunovicFabrizio ContiVincenzo BarnabaSilvia Piconese

Published in: Clinical & translational immunology (2020)

Our results reveal a Treg-intrinsic role of ISG15 in dictating their refractoriness to the IFN signal, thus preserving the Treg population under inflammatory conditions.

Keyphrases

single cell
endothelial cells
high glucose
dendritic cells
diabetic rats
immune response
oxidative stress
cell therapy
genome wide
induced pluripotent stem cells
pluripotent stem cells
drug induced
stem cells
gene expression
dna methylation