Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed.

Reiko UeokaNaoya ShinzatoNoritaka KagayaHikaru SuenagaTeppei Kawahara

Published in: The Journal of antibiotics (2020)

A new lipopeptide, pseudoalteropeptide A (1) was isolated from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4. The structure was elucidated by spectroscopic analyses including NMR and MSMS spectra. It showed moderate iron chelating activity as well as cytotoxic activity against Jurkat human T lymphocyte cells. isolation/marine bacterium/natural product/structure elucidation.

Keyphrases

endothelial cells
induced apoptosis
magnetic resonance
cell cycle arrest
high resolution
high intensity
density functional theory
cell death
molecular dynamics
anti inflammatory
pi k akt