Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.
Xia-Chang WangSherif I ElshahawiWenlong CaiYinan ZhangLarissa V PonomarevaXiabin ChenGregory C CopleyJames C HowerChang-Guo ZhanSean ParkinJürgen RohrSteven G Van LanenKhaled A ShaabanJon S ThorsonPublished in: Journal of natural products (2017)
The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
Keyphrases
- high resolution
- simultaneous determination
- single cell
- mass spectrometry
- genome wide
- liquid chromatography
- ms ms
- computed tomography
- heavy metals
- tandem mass spectrometry
- dna methylation
- particulate matter
- high resolution mass spectrometry
- artificial intelligence
- transcription factor
- capillary electrophoresis
- air pollution