Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions.

Tian LanKaylin C A PalmLuka HoebenErnest Diez BenaventeR Noah PerryMete CivelekDominique P V de KleijnHester M den RuijterGerard PasterkampMichal Mokry

Published in: Atherosclerosis (2024)

Atherosclerotic plaques from current smokers show sex-dependent upregulation of smooth muscle cell gene CRLF1. This may explain the different contributions of smoking to cardiovascular risk in females.

Keyphrases

smooth muscle
smoking cessation
poor prognosis
cell proliferation
signaling pathway
single cell
cell therapy
coronary artery disease
copy number
genome wide
gene expression
mesenchymal stem cells