Glucagon-like peptide-1 receptor agonists in adolescents with overweight or obesity with or without type 2 diabetes multimorbidity-a systematic review and network meta-analysis.

Muhammad Aaqib Shamim Amol N Patil Ulfat Amin Tuli Roy Krishna TiwariNoor HusainJogender Kumar Chenchula Santenna Priyanka Rao Venkata Ganesh Shobhan Babu Varthya Surjit Singh Ravindra Shukla Pankaj Malhotra Aravind P GandhiPrakisini SatapathyRanjit Sah Bijaya Kumar Padhi Pradeep Dwivedi Kamlesh Khunti F MedSci

Published in: Diabetes, obesity & metabolism (2024)

The evidence suggests that GLP-1RAs reduce most weight-related outcomes in adolescents, with semaglutide being the most efficacious. There is uncertain evidence on body fat and serious AEs, probably due to fewer studies and low incidence, respectively. Larger RCTs with head-to-head comparisons, pragmatic design, adiposity-related outcomes, and economic evaluation can further guide the use and choice of GLP-1RAs.

Keyphrases

type diabetes
physical activity
weight gain
weight loss
insulin resistance
young adults
glycemic control
body mass index
metabolic syndrome
optic nerve
risk factors
cardiovascular disease
randomized controlled trial
high fat diet induced
decision making
double blind