Effect of metformin on nonalcoholic fatty liver based on meta-analysis and network pharmacology.

Yuanshe HuangXiaodong WangChen YanChen LiLidan ZhangLai ZhangE LiangTianlei LiuJing-Xin Mao

Published in: Medicine (2022)

Metformin might be a candidate drug for the treatment of NAFLD which exhibits therapeutic effect on NAFLD patients associated with ALT, AST, TG, TC and IR while was not correlated with BMI. HIF1A, NFE2L2, NOS3, NR3C1, PIK3CA, and SIRT1 might be core targets of metformin for the treatment of NAFLD.

Keyphrases

systematic review
end stage renal disease
ejection fraction
chronic kidney disease
oxidative stress
newly diagnosed
randomized controlled trial
combination therapy
peritoneal dialysis
physical activity
patient reported outcomes