Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.
John Barton FurnessRuslan V PustovitAndrew J SyderMitchell T RinguetEun Ji YooAndrea FanjulJill WykoskyLinda J FothergillEmily A WhitfieldSebastian G B FurnessPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Our observations imply that dopamine is a transmitter of the defecation pathways whose actions are exerted through interacting dopamine (D2) and ghrelin receptors on lumbosacral autonomic neurons that project to the colorectum. The results explain the excitation by dopamine agonists and the conservation of GHSR1a in the absence of ghrelin.