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Clinical Impact of Residual C-Peptide Secretion in Type 1 Diabetes on Glycemia and Microvascular Complications.

Anita JeyamHelen Martina ColhounStuart McGurnaghanLuke BlackbournTimothy J McDonaldTimothy James McDonaldJohn A McKnightMark W J StrachanAlan W PatrickJohn ChalmersRobert S LindsayJohn R PetrieRobert S LindsayAndrew CollierSandra MacRuryPaul M McKeiguenull null
Published in: Diabetes care (2020)
These results in a large representative cohort suggest that even minimal residual C-peptide secretion could have clinical benefit in type 1 diabetes, in contrast to a follow-up study of the Diabetes Control and Complications Trial (DCCT) intensively treated cohort where an effect on hypoglycemia was seen only at C-peptide levels ≥130 pmol/L. This has obvious implications for the design and evaluation of trials of interventions to preserve or restore pancreatic islet function in type 1 diabetes.
Keyphrases
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • insulin resistance
  • risk factors
  • physical activity
  • magnetic resonance
  • study protocol
  • randomized controlled trial
  • metabolic syndrome
  • computed tomography